Titanum: Developing JavaScript Desktop Applications

"Titanium" is an open source platform
for developing desktop applications
by using web technologies,
build around WebKit browser, JavaScript language.
It supports multiple OSs, including Windows, Linux, OS X,
as well as multiple hardware platforms (x86, PowerPC etc)
multiple scripting languages: JavaScript, Python, Ruby,
and various plug-ins such as Flash, Silverlight, JavaFX

video @InfoQ

source @github