no jQuery anymore, but no React, Angular or View either
They do use TypeScript though!
GitHub's Journey with Web Standards and Web Components @InfoQ
"The starting point to write a new Web Component at GitHub is Catalyst, a framework relying on TypeScript and decorators to reduce boilerplate and adopting an observe, listen, query approach to handle state change and user interaction. GitHub also created a Web Components linter which is used along its generic JavaScript linter."
How we use Web Components at GitHub | The GitHub Blog
Removing jQuery from GitHub.com frontend | The GitHub Blog
Catalyst
"Web Components made easy"